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KMID : 0043320120350030423
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Archives of Pharmacal Research
2012 Volume.35 No. 3 p.423 ~ p.430
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Phytochemical studies of the phenolic substances in Aster glehni extract and its sedative and anticonvulsant activity
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Nugroho Agung
Kim Myung-Hoe
Choi Jong-Won
Choi Jae-Sue
Jung Won-Tae
Lee Kyung-Tae
Park Hee-Juhn
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Abstract
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On high performance liquid chromatography, the caffeoylquinic acid (CQ) occupying the highest proportion of the water-ethanol (7:3) extract of Aster glehni (Compositae) leaves was 3-Op-coumaroylquinic acid (46.10 ± 4.22 mg/g of dried weight) among CQs tested. The IC50 of the water-ethanol (7:3) extract was 4.23 ± 0.24 μg/mL in the peroxynitrite (ONOO?)-scavenging assay. Phytochemical isolation from A. glehni extract yielded three kaempferol glycosides. The water-ethanol (7:3) extract and both p-coumaric acid and caffeic acid, phenylpropanoid moieties of CQs, had sedative effects in pentobarbital-induced sleeping time in mice and anticonvulsant effects in pentylenetetrazole-induced mice. Furthermore, the phenolic substance-rich W-E (7:3) extract of A. glehni could be used to treat anxiety or convulsion partly due to its peroxynitrite-scavenging mechanism.
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KEYWORD
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Aster glehni, Compositae, Caffeoylquinic acid, Sedative, Anticonvulsant, Peroxynitrite, High performance liquid chromatography
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